Actiponin AMP-K Stimulator

Activate the body’s metabolic master switch to help burn fat for greater energy and vitality with Swanson Actiponin® AMP-K Stimulator. Scientists have found that many of the benefits of aerobic and anaerobic exercise stem from the activity of an enzyme known as 5’ adenosine monophosphate-activated protein kinase, or AMP-k, often called the “metabolic master switch.” During exercise, physical stress on the muscles and bones triggers the up-regulation of a family of proteins known as sestrins, which in turn activate the AMP-k enzyme. When AMP-k is activated, it triggers a cascade of metabolic effects that influence fat burning. The net result is improved muscular performance, reduced body fat and optimized metabolic activity.

Actiponin is a powerful herbal extract that activates the AMP-k enzyme, much like physical exercise does. It’s derived from Gynostemma pentaphyllum (also known as jiaogulan), a calming adaptogenic herb that has been used for centuries as a longevity tonic, sometimes known as “the immortality herb.” Scientists have identified natural saponins in gynostemma known as damulins which have been shown to strongly activate AMP-k in phytochemical studies. Our formula includes Actiponin®, a patented nutraceutical from Gynostemma pentaphyllum leaf, containing 1.2% of Damulin A, the active saponin component. Actiponin® naturally contains Damulin A and Damulin B, which together demonstrate better efficacy in activating AMPK, in comparison to other standardized extracts from G. pentaphyllum.¹

Actiponin has been clinically studied for promoting fat metabolism showed significant decreases in BMI, weight, body fat and abdominal body fat with 12 weeks of consistent use.² But the benefits of Actiponin go beyond weight control; by activating AMP-k you can enjoy many of the metabolic advantages that could otherwise only be obtained through strenuous physical exercise.

Increase exercise performance and aid post-workout recovery, stimulate energy production, promote healthy aging and get help meeting your weight management goals, all by supporting your body’s production of AMP-k. 

Looking for a Companion to Your GLP-1 Weight Management Journey?

If decreased caloric intake has you feeling sluggish, supporting AMP-K may be what you need. AMP-K helps to regulate energy in the cells by either triggering energy production or inhibiting energy consumption as needed. Actiponin® can help—as an AMP-K stimulator it has been clinically studied to promote a healthy weight and BMI, and help manage total fat mass and localized fat accumulation.¹ Studies showed an average 11% loss of visceral fat and 3.9% total body fat.² Actiponin also supports aerobic fitness, making sure cells throughout the body have the oxygen they need for optimal performance.

Source: (1) Nguyen PH, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60. Epub 2011 Sep 10. (2) Park SH, et al. Obesity (Silver Spring). 2014 Jan;22(1):63-71. Erratum in: Obesity (Silver Spring). 2015 Dec;23(12):2520. Erratum in: Obesity (Silver Spring). 2020 Sep;28(9):1770-1773.